i have had prolonged bouts with some debilitating stuff. you literally feel like you're in a bubble. sometimes you don't see and hear things that are right there. it's not black and white obviously. everyone is different and normally the very worst stuff only comes in waves. the effects of feeling so isolated can start to wear on you though after a while. when you're interacting with other people all day and cant feel a connection, or cant feel anything, its awful.