I'm running a MSI MEG Z490 ACE Gaming Motherboard (ATX, 10th Gen Intel Core, LGA 1200 Socket, SLI/CF, Triple M.2 Slots, USB 3.2 Gen 2, Wi-Fi 6) mobo which I filled all 3 slots.There might be a motherboard that can support more than one, but I've never seen that.
*edit - and of course, it is a little cheaper than when I bought it. When I bought it, it took 4 weeks to get it due to inventory being next to nonexistent.