I like the Orville. It's not the greatest show ever but I'm down to watch it.
The thing about Trek which I don't think the Orville has the ability to match is character development. Even a series as poorly regarded as Voyager actually had meaningful development for Tom, B'lana, The Doctor and Seven (even though the doctor and seven both served the same purpose as a foil for humanity.... which is what Data's character was in TNG and Spock in TOS). Most of these were one-dimensional archetypes who grew into something more.
Look at Bortus - When he's a punchline he's great but when there's some sort of moral challenge or development of character, it just doesn't fit. The same would go for the other 'punchline characters' like Isaac, Gordon or John. They work as a cartoon of a person but fall flat when asked to be taken seriously. Alara was probably the best character they had done anything with and now she's off the show, lol.
Most of the crew are portrayed with an undertone of ineptitude. The show works better as a space (mis)adventure than it does when it asks us to then believe these characters in a serious tone.