n 2009, she completed 43 marathons in 51 days for Sport Relief despite having no history of long-distance running. In 2016, she ran 27 marathons in 27 days in South Africa in honour of Nelson Mandela, raising £1.35 million. Regularly performing in French, among other languages, Izzard is an active supporter of Europeanism and the European Union. A dedicated Labour Party activist, she twice ran unsuccessfully for the party's National Executive Committee but temporarily joined as runner-up after Christine Shawcroft resigned in March 2018. Izzard is genderfluid and has said she prefers she and her pronouns, but "doesn't mind" he and him.
zzard was named on a list of the biggest private donors to the Labour Party in 1998;[64] in 2008, she donated nearly £10,000.[65] She has appeared in party political broadcasts for the Labour Party in the run-up to the 2005 general election and 2009 European election, as well as a 2010 election video entitled Brilliant Britain. During the 2015 general election, she attended a rally with fellow comedian Ben Elton and actor Sally Lindsay.[66] Expressing support for Labour in the 2017 UK general election, she said that Jeremy Corbyn "believes in what he says."[67]
Izzard has at various times said she would run for Mayor of London in 2020.[68][69] Asked on a comedy panel show, The Last Leg, why she would be elected, Izzard replied, "Boris Johnson".[70] She unsuccessfully ran for a seat on the National Executive Committee of the Labour Party in 2016 and 2018.[71][72][73] After Christine Shawcroft resigned in March 2018, Izzard replaced her as the next runner-up, but failed to secure re-election that summer.