We have instas for the entire Lonetrek region, and for Torrinos -> L-C307, Korama -> L-C307, and for a lot of the Fade region where C4C-Z4 (refinery), L-C307 (Corp Office), and our POS (8S2S-Q?) are located. (Join the corp, ask for them, and ye shall receive.

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With instas, you are pretty much invulnerable once in warp (unless you get caught by a bubble [mobile deployable warp disruptor]) if you jump as soon as you exit warp. Where you have to watch yourself is once you go through a gate. There could be a camp on the other side (like you stated above...5+ pirates/enemy alliance members).
The problem here will be that you are vulnerable while entering warp. If your ship is quick enough, they wont be able to lock you before you warp. If they try to disrupt you, you will pretty much be helpless against multiple quick lockers/disuptors. If you are going up against two pirates with -2 disuptors, you will need at least 4 WCS to prevent them from catching you.
Otherwise, if you have 2 WCS, you should be safe... relatively....scared yet?
There is danger out in 0.0 of course, mainly from very experienced solo PVP'ers, or from 2 or more in a squad. If you take the above precautions though, you should come out of a hairy situation still in tact.
It is one hell of an adreniline rush though when you get away after taking some damage...
Oh, make sure you check local chat, and do a show info on anybody you don't recognize to check their relationship standing. If they are hostile, WATCH OUT!! If they are neutral, BE CAREFUL! Rules vary from Fade to Deklein region, where neutral is Kill On Sight (KOS) in Dek, and verify friendly in Fade.
Join the Fade Con and Dekcom channels and report any enemy movement you see. DO NOT REPORT FRIENDLY ACTION SUCH AS FRIENDLY GATE CAMPS!!!! ENEMIES MAY BE WATCHING!!!
